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By Max Meyer

What’s in store for NFL Week 4? There are the first NFC West matchups of the season, the biggest spread of the season and Tom Brady’s highly anticipated return to New England with a monumental record well within reach.

We’ve seen a lot of Tom Brady and Bill Belichick in primetime over the past couple decades, yet this is the first time they’ll be opposing each other. Brady and the Buccaneers head to Foxborough on Sunday night to face off against Belichick and the Patriots.

Tampa Bay is -6.5 against New England at Caesars Sportsbook. That currently makes the Bucs the third-biggest road favorite on the slate, trailing the Titans (-7.5 at the Jets) and the Chiefs (-7 at the Eagles). The total for this matchup resides at 49, which is currently Tampa Bay’s lowest total in a game this season and New England’s highest.

There is just one battle between undefeated squads this week, and it happens to be a divisional duel. The Rams host the Cardinals with a 4-0 record and first place in the NFC West on the line. Los Angeles is the +110 favorite to end up with the division crown, followed by the 49ers at +275. The Cardinals are now in the third spot at +375, with the Seahawks bringing up the rear at +650.

The Rams are 4.5-point chalk at home, as they are 2-0 against the spread in Los Angeles this campaign. Something has to give, though, as the Cardinals are 2-0 against the spread on the road thus far. This affair is also tied for the highest total on the board this week at 54.5, joining Chiefs at Eagles.

One Nevada bettor already placed a $300,000 wager on Cardinals +6 (-110) for a total potential payout of $572,727.27. That is the biggest NFL Week 4 bet taken thus far at Caesars Sportsbook.

Meanwhile, the Seahawks are in the midst of a two-game skid and will look to get back on track in the Bay Area. The 49ers are 2.5-point favorites against Seattle, with the total positioned at 52.5. San Francisco is one of three teams favored by under a field goal at home in Week 4, as well as the Broncos (-1.5 vs. Ravens) and Dolphins (-1.5 vs. Colts). There have been five home favorites that have closed at 2.5 or fewer at Caesars Sportsbook this season, and they’ve gone both 1-4 straight up and against the spread.

Finally, the first two-touchdown underdog of the season has graced our presence. The Texans are at +16.5 at Buffalo against the Bills, with Houston’s moneyline priced at +850 and Buffalo at -1600. The Texans previously closed as the biggest underdog in 2021 back in Week 2, when they ended up at +13.5 at the Browns. Double-digit underdogs are 1-3 against the spread on the season, with only Houston covering after falling 31-21 to Cleveland.

Check out Caesars Sportsbook’s latest odds for every Week 4 game of the NFL season below.