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By Max Meyer

The calendar has flipped to October, and this month starts with a monster Sunday slate for NFL Week 4. We have the biggest spread at Caesars Sportsbook of the NFL season, the biggest spread bet taken at Caesars Sportsbook this NFL season and the most-anticipated matchup of the NFL season.

Tom Brady and Bill Belichick spent 20 seasons together with the Patriots before Brady departed last offseason and joined the Buccaneers. Now the legendary quarterback and head coach face off for the first time ever this Sunday night in New England.

“This will be the biggest regular season game of the year in terms of handle and interest,” said Craig Mucklow, Vice President of Trading at Caesars Sportsbook. “The storylines and Brady coming off a loss will continue to drive public money on the Bucs and the over. Bettors are also looking to bet alternate spreads thinking that Brady will blow his former team out and run the score up on Belichick.”

The Buccaneers opened as 5.5-point road favorites over the Patriots, and the spread has since jumped up to -7. Tampa Bay has been getting an astounding 96% of the total number of tickets and 97% of the total dollars wagered on all spread bets against New England.

If those percentages seem rare for NFL, that’s because they are. Only two NFL teams have brought in at least 90% in both categories on a respective spread this season for Friday trends: Chiefs -3.5 (90% tickets, 93% dollars) at Ravens in Week 2 and Cardinals -7.5 (95% tickets, 96% dollars) at Jaguars in Week 3.

The Buccaneers getting 97% of the total dollars wagered is the most lopsided betting action on any spread this season. The 96% for total number of tickets is tied for the highest percentage of the season along with another spread this weekend: Titans -6 at Jets.

Tennessee was originally 6.5-point road chalk and reached as high as -7.5 during the week. This spread, though, has gone down to Titans -6, as the home underdog has drawn a massive wager. A Nevada bettor put $300,000 on Jets +7 (-120) for a total potential payout of $550,000, which has led to New York having the advantage in total dollars wagered on this spread at 60%.

That isn’t even the bigger NFL Week 4 bet at Caesars Sportsbook. That would belong to the biggest favorite of the season so far. Another Nevada bettor staked $500,000 on Bills -16.5 (-110) against the Texans for a total potential payout of $954,545.45, the biggest spread bet of the season at Caesars Sportsbook.

Overall, the Bills have racked up 96% of the total dollars wagered, which only trails the Buccaneers in that department this week. With all of those points, the total number of tickets has been relatively split, as Buffalo has the edge there at 57%.

The Bills opened as massive 17.5-point chalk at home over the Texans, fell to as low as -16 and are now back up to -17. Houston previously was the biggest underdog of the season back in Week 2, when the Texans closed at +13.5 at the Browns.

Buffalo is also the heaviest-priced moneyline of the NFL season, with the Bills now residing at -1700 and the Texans at +900 to notch the outright upset. Another Nevada bettor put $95,000 on Bills ML -2000 for a total potential payout of $99,750.

There have been four other six-figure NFL Week 4 spread wagers placed at Caesars Sportsbook so far—$300,000 on Cardinals +6 (-110) at Rams, $275,000 on Giants +7.5 (-110) at Saints), $275,000 on Browns -2 (-110) at Vikings and $275,000 on Dolphins -2 (-110) vs. Colts.

We’ve talked mostly about favorites thus far, so let’s key in on two underdogs that have gotten noteworthy action.

A pair of road teams getting a field goal in divisional duels are receiving the majority of the total number of tickets and total dollars wagered on their spreads. The Lions (+3 at the Bears) have snagged 80% of the total number of tickets and 76% of the total dollars wagered, while the Seahawks (+3 at the 49ers) have the advantage in this NFC West showdown with 67% and 62% respectively.

Check out Caesars Sportsbook’s latest odds and trends for every upcoming NFL Week 4 spread below.